Im thinking about changing out the spark plugs and wires on my 98 SE, will there be any real change in throttle response and MPG and would it be worth it?

We can't really tell you. It depends on the age, condition, and type you're running now.

Can you give us more details?

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It depends. More than likely you'll notice a change in throttle response. I did, BUT that was changing out 8 year old stuff. MPG might've gone up a little bit.

Like willwren says, it depends.

Now whether it's a good idea to put new ones in there, of course it's a good idea if you don't know their history, or it's been a few years.

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2012 Chevrolet Cruze Eco - Current car

1999 Buick LeSabre Custom - Former car

Learn from the mistakes of others, that way when you mess up you can do so in new and interesting ways.

Whatcha gettin NGKs and Beldens?

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1988 SSE-Gone but not forgotten.
2001 SSEI-304,572 miles, 3.5 Pulley, Intense PCM, Intense FWI Spectre filter, 160 tstat, ngk iridiums, belden wires, Silverstars-high and low beam, rebuilt tranny, shift kit, cooler, Dex VI fluid, replace the rear compressor and lines and level sensor, Monroe air shocks in back, FE5 struts and Moog strut mounts, Moog stabilizer bars, AC\Delco control arms.

2004 SLE-Stock, 195,000 miles,oldest son's baby now

2000 Ford Ranger-Stock, 352,000 hard, pizza delivery miles, new control arms (upper and lower), new(used) tranny

Right now the Bonnie has got 75,000 miles on it and the plugs and wires are probably stock. as far as what kind to put in i really have no clue ive just been doin some research and checkin what would be best. Any suggestions on what to get? and does changing the plugs and wires affect anything else that would have to be changed?

Plugs and wires are simple and straightforward. I would recommend NGK TR55 plugs and Beldin Premium Wires from NAPA. You don't need to change anything else. A dab of anti-seize compound on the threads of the plugs and some of the (generally supplied) di-electric grease in each of the boots on the wires will help them come off easier next time. I guarantee new plugs and wires will make a difference in your car, how much, I can't say.

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Awesome, thanks for the info!

If napa wants too much, my car is using Autolite wires from Advance. $30 and lifetime warranty. They take your phone number for lookup later.

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2012 Chevrolet Cruze Eco - Current car

1999 Buick LeSabre Custom - Former car

Learn from the mistakes of others, that way when you mess up you can do so in new and interesting ways.